Liked your post. Let me throw in my 2 cents:
1) Land Grab
Go back to the run-for-it grab with a delay based on rank! Awesome....
2) Development
1 round of development -- all 5 players! Make Mule 2 a fast game, that'd really differentiate it and make it popular in a unique way.
3) 4/5 players
Can we make it 4 or 5? I'm afraid more players just means more AIs and preying on a clueless noob to always win.
4) 3d Auction
I agree with others, kind of a waste of screen space and not very practical. I would go to a 2d version.
5) Bar
If a player waits there too long because he's putzing around at break, have his character drink beer. When he plays, have him wander drunkenly as punishment.
6) Assaying
The 1/2/3 stuff needs to stay longer in the round so people can see it. Just have it stick through development, helps with the multiplayer mode. How about L/M/H instead?
7) Order
I'd rather see the squares reorder than the numbering, which is too subtle.

Random connection crap on right side
The top two numbers that jump around like crazy should go away.
9) River
Have it still during play and run during production!
10) Good/Bad News blurb pictures
Liked those!
11) Colors
Still with the purple? Can we have a black instead? Maybe make this more selectable from a wider palette?
12) Auction Land Store
No!